Motorists can take Highway No. 35 from Bangkok to Samut Songkhram, then shift onto No. 325 to Amphawa.
Buses leave from Bangkok Southern Terminal to Samut Songkhram (Mae Klong) daily.
There are also vans to Mae Klong leaving from the Victory Monument.
Trains leave from Bangkok's Wong Wian Yai station. In Samut Songkhram, you can find local transport to Amphawa.